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Successful therapy of peritoneal mesothelioma with intraperitoneal chemotherapy alone. A case report.
Abstract: Malignant peritoneal mesothelioma is a disease that remains relatively refractory to conventional intravenous chemotherapy with currently available agents. Single-agent and combination chemotherapy offer a response rate of 20%. Direct intraperitoneal administration of some chemotherapeutic agents results in a significant pharmacologic advantage with much greater area under the concentration versus time curve (AUC). We report a case of a patient with peritoneal mesothelioma treated with combination intraperitoneal cisplatin and Ara-C who achieved a pathologic complete remission. This patient is still alive and has been in complete remission for 53 months. This combination of intraperitoneal chemotherapy deserves further evaluation in malignant mesothelioma.
Garcia Moore ML
Section of Medical Oncology, University of Miami School of Medicine,
Florida 33121.
Am J Clin Oncol
1992 Dec, vol 15, pages 528-530
UNITED STATES
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